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A pipe size/macro-mixing combination can be used for a range of flowrates.  An increase in flowrates will result in a higher head loss for the macro-mixing orifice.   This can actually result in the macro-mixing orifice having a higher head loss than the micro-mixing orifice.  Due to this, the user can select a constraint value for head loss (usually 2 to 10 cm, currently set at 5 cm) that will cap how high the macro-mixing head loss can be.  This is done by selecting a larger pipe size and larger macro-mixing orifice.  In figure 2, the results for head loss through the macro-mixer are shown below.  At high flow-rates, macro-mixing head loss becomes higher than micro-mixing head loss. 

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With the head loss of the entire plant and the entire system accounted for the constraint on the macromixer headloss (MacroMHConstraint = 5 cm) the size of the nominal diameter of the pipe, the diameter of the macromix orifice and the size and number of micromix orifices can be determined.

Figure 2:  Rapid mix sizing algorithm for lower flow rates with 20 cm through micro-mixer and no constraints 

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