29 August 2018: Booting up
5 September 2018: Thom Cleland
12 September 2018: Christiane Linster
19 September 2018: Jesse Werth
26 September 2018 (t): No meeting
3 October 2018 (t): No meeting
10 October 2018: Christiane Linster
17 October 2018: Ayon Borthakur
24 October 2018: No meeting
31 October 2018: Francesco Cavarretta
7 November 2018: Jack Cook
14 November 2018: Marlene Berke (guest speaker)
Here's a paper that would be a good background:
http://www.nature.com.proxy.library.cornell.edu/articles/nn.2948
It doesn't have to be read in detail, just to get some familiarity with the ideas of the Signal Detection Theory model, perceptual signal strength (d'), criterion bias, etc... I'm trying to show that the findings about spatial attention inducing a conservative bias also hold for content-based attention.
21 November 2018: Thanksgiving Break (no meeting)
28 November 2018: Matt Einhorn
5 December 2018: David Field (guest speaker)
Friday, 7 December 2018: CPL Undergraduate Symposium
8 February 2018: Booting up
15 February 2018: Christiane Linster
22 February 2018: Ayon Borthakur
1 March 2018 (t): No lab meeting (Thom and Ayon out of town)
8 March 2018 (t): No lab meeting
15 March 2018: Francesco Cavarretta
22 March 2018: Jack Cook - Analytical model of odor learning
29 March 2018: Jesse Werth - Methods of spike train analysis
5 April 2018: Guest lecture/discussion by Elisa Galliano (Kings College, London)
How do environmental changes affect neuronal structure and function? Within a holistic framework we aim to investigate how sensory experience induces neuronal plasticity on multiple, interacting levels in a well-defined cell population: dopaminergic (DA) neurons in the olfactory bulb (OB).
Bulbar DA cells are very plastic interneurons that are capable of regenerating throughout life and that modulate information transfer at the first synapse in olfaction. They have been long treated as a homogeneous population. However, we have identified two distinct subclasses of OB DA neurons, defined by the presence or absence of the axon initial segment (AIS). AIS-positive DA neurons have a large soma and an extended dendritic tree, and are generated exclusively during embryonic development. Conversely AIS-negative DA neurons are small, narrowly-ramified, axonless cells that are continuously generated throughout life. AIS-positive neurons are more intrinsically excitable than AIS-negative cells, and for certain long-latency responses are more broadly tuned to odours.
These morphological, physiological and developmental distinctions place important constraints on the functional roles of OB DA neurons in sensory processing, and on their potential for plasticity. We therefore assessed experience-dependent plasticity in bulbar neurons in juvenile mice that underwent sensory deprivation via 24h unilateral naris occlusion. In AIS-positive DA cells, occlusion produced decreased intrinsic excitability correlated with a shorter AIS. These plastic modifications were cell-type-specific – they were not observed in AIS-negative DA cells or in any glutamatergic OB neurons – and therefore underscore the importance of cell identity in determining the potential for plasticity in response to environmental perturbations.
12 April 2018: Preparation for the AChemS Meeting
19 April 2018: AChemS Meeting – NO LAB MEETING
26 April 2018: Matt Einhorn - A generative vision model
3 May 2018: Thom Cleland
Friday, 11 May 2018: CPL Undergraduate Symposium
30 January 2017: Booting up
6 February 2017: Christiane Linster
13 February 2017: Matt Lewis
Hagiwara et al. 2012 Optophysiological analysis of associational circuits in the olfactory cortex. http://journal.frontiersin.org/article/10.3389/fncir.2012.00018/full
Wang and Sun 2012 Characterization of axo-axonic synapses in the piriform cortex of Mus musculus. http://onlinelibrary.wiley.com/doi/10.1002/cne.22792/abstract;jsessionid=88BE6E00FE28877941A284F0250BBCD3.f04t02
20 February 2017: CORNELL BREAK - NO LAB MEETING
27 February 2017: Joint lab meeting with Smith lab. Meeting will be in 205 Uris Hall – not in the Rosenblatt room as usual.
6 March 2017: Jesse Werth
13 March 2017: No meeting
20 March 2017 (t): TBD
27 March 2017: Matt Einhorn
3 April 2017: CORNELL SPRING BREAK - NO LAB MEETING
10 April 2017: TBD <no Thom for a chunk of April, details TBD>
17 April 2017: TBD
24 April 2017: TBD
1 May 2017: Cancelled.
8 May 2017: Francesco Cavarretta
5 February 2015: Christiane Linster
12 February 2015: Round the table
19 February 2015: Ayon Borthakur
26 February 2015: Michelle Tong
5 March 2015: No lab meeting
12 March 2015: Matt Lewis
19 March 2015: Christiane Linster
26 March 2015: TBD
2 April 2015: TBD
9 April 2015: TBD
16 April 2015: TBD
22 April 2015: TBD (c)
30 April 2015: TBD
7 May 2015: TBD
Friday, 8 May 2015: CPL Undergraduate Symposium, 11:30 - 3:00 pm in the Whitaker Room (4th Floor Mudd Hall). Note that this is 90 minutes earlier than usual owing to room availability; we have the Whitaker room reserved from 11:00 am - 3:30 pm.
July 31 2014
Matt Lewis will discuss a new paper from the Strowbridge lab, titled: Modulation of olfactory bulb network activity by serotonin: synchronous inhibition of mitral cells mediated by spatially localized GABAergic microcircuits. (PDF is attached here).
Jan. 30 2014
Licurgo gave us an overview of his large OB->PCx->HDB model
Feb. 6 2014
Michelle gave us a practice version of her 4th year Psych talk
Feb 13 2014
Matt L presented work related to 5-HT in the bulb (behavior, modeling, slice data)
Feb. 20 2014
No Meeting
Feb. 27 2014
Guoshi presented his recent modeling work looking at gamma oscillations within the olfactory bulb
(PDFs of papers mentioned during the meeting are here. Buzaki et al. 2012 (LFP review), and Reimann et al. 2013 (latest Blue Brain work looking at simulated cortical columns and the role of particular ACTIVE currents in the genesis of LFPs)
Mar. 6 2013
No Meeting
Oct. 17, 2013
Assigned Reading: Reciprocal connectivity between mitral cells and external plexiform layer interneurons in the mouse olfactory bulb.
Oct. 24, 2013
Assigned Reading: Equalization of odor representations by a network of electrically coupled, inhibitory interneurons
Supplemental Materials: Zhu et al. SI.pdf
November 21, 2013 M. TONG
Primer: Epigenetics in Learning and Memory
Reading: DNA meth reward learning JJ Day et al 2013 Nat Neurosci.pdf
Extra reading: Two articles written by Sweatt and colleagues.
-1) a smallarticle about the emerging field of neuroepigenetics
-2) a more substantial review about the role of epigenetic genomic modifications in cognition.
Nov. 29, 2012. Matt Lewis. Odor representations and neuromodulators.
Neuromodulation:
Associative cortex features in the first olfactory brain relay station.
Plus all the work from the CPL
Coding:
Encoding Odorant Identity by Spiking Packets of Rate- Invariant Neurons in Awake Mice
Rat Olfactory Bulb Mitral Cells Receive Sparse Glomerular Inputs
Robust Odor Coding via Inhalation-Coupled Transient Activity in the Mammalian Olfactory Bulb
Again this list is far from exhaustive but they are a few papers that touch on the subject matter I would like to discuss on Thursday.
Fridays from 9:00 - 10:30 a.m. in W358 Corson-Mudd Hall.
Lab meetings for spring 2011-12 are not being logged here. However, there is information here about the...
The Tenth CPL Undergraduate Research Symposium will be held on Monday 7 May 2012, from 1:00 - 5:00 pm (during study week), in the Whitaker room. The Whitaker room is on the fourth floor of Corson-Mudd Hall; take the elevator (or the adjacent stairwell) to the fourth floor, bear left as you emerge and the door is right in front of you. (The atrium stairwell does not go up to the fourth floor).
Fridays from 9:00 - 10:30 a.m. in W358 Corson-Mudd Hall.
9 September 2011 : Christiane Linster
16 September 2011 : Anuttama Sheela Mohan
23 September 2011 : Shane Peace
30 September 2011 : Christiane Linster - new paper from Dima Rinberg's lab: Shusterman et al 2011.
7 October 2011 : Thom Cleland - chips and the treacherous reverse problem
14 October 2011 : Guoshi Li - Network OB model, focusing on cholinergic neuromodulation
21 October 2011 : Amita Verma and IACUC presentation to the lab
28 October 2011 : Sasha Devore
4 November 2011 : Preparation for SFN - have your posters "mostly ready" by this date to show in lab meeting (prob. electronically)
11 November 2011: SOCIETY FOR NEUROSCIENCE MEETING - DEPARTING TOMORROW (SAT 12 NOV)
18 November 2011 : Jenny Davie, postdoc with Andreas Schaefer's lab
25 November 2011 : No meeting - thanksgiving break.
2 December 2011 : SFN debriefing and summary of key abstracts (everybody contributes).
The CPL Undergraduate Research Symposium will be held on Monday 5 December, from 1:00 - 5:00 pm (during study week), in the Whitaker room. The Whitaker room is on the fourth floor of Corson-Mudd Hall; take the elevator (or the adjacent stairwell) to the fourth floor, bear left as you emerge and the door is right in front of you. (The atrium stairwell does not go up to the fourth floor).
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18 May 2011: Matt Lewis presents two recent anatomical surveys of olfactory system connectivity with reciprocal approaches. Miyamichi et al. used retrograde trans-synaptic labeling to trace the origin of mitral/tufted cell axons, while Sosulski et al labelled M/T cells of single glomeruli and followed their axons to the PCx, EC, Amyg, and AON. Both papers attempt to quantify the connectivity between these areas.
1 June 2011: Sasha Devore presents two papers discussing "innate olfactory behaviors." Kobayakawa et al produced mice lacking OSNs in the dorsal zone of the OB, and a separate strain with complete ablation of class II OSNs (kind of, but not quite a ventral zone ablation). The main finding that while mice are able to still able to detect and form associations with olfactory stimuli, the innate non learned behavior (assayed through an avoidance/attraction test) is altered in dorsal zone OSN knock out mice. Innate responses to aversive odorants were lost suggesting that aversive information is received in the olfactory bulb by separate sets of glomeruli. This idea is supported by the result in Miyamichi et al (the week prior) that suggested that inputs from the olfactory bulb to the cortical amygdala are predominately from the dorsal zone of the OB. The second paper, Sakamoto et al, uses a "Nestin-CreERTM;neuron-specific enolase-diphtheria toxin fragment A" line that selectively depletes the forebrain (dentate gyrus and olfactory bulb) of newly born neurons. While mutant mice and wild type mice still exhibited freezing behaviors in response to TMNT (fox scent) the mutant animals were able to learn to approach the TMNT with appetitive conditioning. Mutant mice also showed altered social behaviors. Male mice showed aberrant male-male antagonism and copulation behaviors with females, whereas mutant females displayed deficits in fertility and nurturing.
8 June 2011: Guoshi Li presents two modeling papers from the Shepherd Lab. The first, Migliore and Shepherd (2008), examined the role of action potentials travelling along the lateral MC dendrites and the role granule cells could play in gating AP propagation. They show how these connections may be able to activate lateral inhibition between distant glomeruli. These results were highly contingent on the network architecture. The second paper, Migliore et al 2007, provided a model suggesting that olfactory columns are able to self-organize through an activity-dependent dendordendritic synaptic mechanism, similar to the first paper, action potentials along the MC lateral dendrites play an important role in this mechanism.
15 June 2011: Sam Dillon
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Fridays from 9:00 - 10:00 a.m. in W358 Corson-Mudd Hall; may extend later. After departmental chalk-talks are over we may or may not return to our 9:30 start time. Lab meetings in general should not be cut-and-dried presentations, but frameworks with outstanding questions where enough background information is provided/available to enable those questions to be wrestled with effectively by us all. So, know your stuff, but no need to overprepare.
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18 February 2011 : Anuttama Sheela Mohan covers metrics of spike timing etc.. Please read this introduction to metric spaces(from The Princeton Companion to Mathematics). You may then find it interesting to look at Jonathan Victor's page on cost-based metrics as applied to spike trains.
25 February 2011 (t): No meeting.
4 March 2011: Tanya Nauvel covers probability and maximum-likelihood estimation (MLE), and its utility for neural data analysis. Here is her introduction to probability, and this tutorial on maximum likelihood estimation. Here also is a pdf of a Mathematica workbook about MLE (talk to Tanya if you want to see the Mathematica code in action), and a paper describing the Poisson model of spike generation in neurons.
11 March 2011:
18 March 2011:
25 March 2011:
7 April 2011: I (Matt L) will be presenting two papers looking at functional connectivity in the rat olfactory system during differing strengths of anesthesia/slow wave sleep. Wilson 2010; Fontanini 2005; Review by Fontanini and Bower 2006. Original paper by Fontanini and Bower 2003, looking at slow rhythms in tracheotomzied rats and establishes the relationship of respiration and slow oscillations in ketamine/xylazine anesthetized rats.
The following are here to add to the papers for background. Here are three sequential papers from a 1993 issue of JNeurosci. 1993a Steriade et al. reports this novel slow <1Hz cortical rhythm in the cat under differing anesthetics. 1993b reports intracellular recordings of the cortical <1Hz slow rhythm and its relationship to Delta and Spindle rhythms. 1993c reports on the presence of this slow cortical rhythm in thalamic cells. Also this review is pretty good background on the purported three individual rhythms in the delta band and slower.
Calcium signal coherence analysis paper from Webb/RHW collaboration.
The CPL Undergraduate Research Symposium will be held on Monday 9 May, from 1:00 - 5:00 pm (during study week), in the Whitaker room. The Whitaker room is on the fourth floor of Corson-Mudd Hall; take the elevator (or the adjacent stairwell) to the fourth floor, bear left as you emerge and the door is right in front of you. (The atrium stairwell does not go up to the fourth floor).
-----------------------------------------------------------
Fridays from 9:30 - 11:00 a.m. in W358 Corson-Mudd Hall. Lab meetings in general should not be cut-and-dried presentations, but frameworks with outstanding questions where enough background information is provided/available to enable those questions to be wrestled with effectively by us all. So, know your stuff, but no need to overprepare.
--
10 September: Matt Lewis leads a discussion of serotonin in the olfactory bulb: where it comes from, where it goes, who is listening when it gets there, and what they do about it.
17 September: Sam Dillon, discussing olfactory habituation techniques & data.
24 September: Christiane Linster.
1 October: Nate Morris, discussing his summer research in Erik Knudsen's lab (auditory localization in barn owls).
8 October: Cancelled.
15 October: Thom will talk about some hypotheses for external plexiform layer function.
22 October: Topic TBD.
29 October: Topic TBD.
5 November: Topic TBD.
12 November: Topic TBD.
19 November: Topic TBD.
26 November: Probably no meeting (thanksgiving weekend). Watch this space.
3 December: Topic TBD.
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The CPL Undergraduate Research Symposium will be held on Monday 6 December, from 1:00 - 5:00 pm (during study week), in the Whitaker room. The Whitaker room is on the fourth floor of Corson-Mudd Hall; take the elevator (or the adjacent stairwell) to the fourth floor, bear left as you emerge and the door is right in front of you. (The atrium stairwell does not go up to the fourth floor).
Fridays from 10:00 - 11:30 a.m. in W358 Corson-Mudd Hall.
22 January: Organizational meeting; presentation by Christiane and/or Thom
29 January: No meeting.
5 February: Sam Dillon
12 February (Recruitment weekend): ???
19 February: Guoshi Li
26 February: Billy Podlaski
5 March: Anuttama Sheela Mohan
12 March: Laura Manella
19 March: SiWei Luo
26 March: Spring Break - no lab meeting
2 April: Shane Peace
9 April: Leo Arellanos
16 April: Olga Escanilla
23 April: Erin Johnson: Presenting Wesson et al (2010) on amyloid beta and olfactory dysfunction.
30 April: Sasha Devore
7 May: Marilyn Juarez
The CPL Undergraduate Research Symposium will be held on Monday 10 May, from 1:00 - 5:00 pm (during study week), in the Whitaker room. The Whitaker room is on the fourth floor of Corson-Mudd Hall; take the elevator (or the adjacent stairwell) to the fourth floor, bear left as you emerge and the door is right in front of you. (The atrium stairwell does not go up to the fourth floor).
Fridays from 10:00 - 11:30 a.m. in W358 Corson-Mudd Hall. [NOT the Rosenblatt Room]
4 September: Organizational meeting; presentation by Christiane and Thom
11 September: Christiane. We will discuss a paper by Nathalie Mandairon's group showing that neurogenesis is required for enrichment to modulate perception.
18 September (t): Ted will present a recent paper from the Strowbridge Lab on the plasticity of granule cell synapses. This previous paper from the same lab is good background.
25 September: NO MEETING.
2 October (t): Shane Peace will present a paper by Kelsch et al. (2009).pdf
9 October: Erin Johnson (CMJC paper).
16 October: Anuttama Sheela Mohan will present an overview and primer on field potential oscillations in the olfactory bulb: theory, data, and comparisons with other systems. Emphasis will be on gamma and beta-band oscillations.
23 October: Sasha Devore.
30 October: Marilyn Juarez will present this paper: 5-HT modulation of odor input to mammalian olfactory bulb.pdf
6 November: Leo Arellanos.
13 November: SiWei Luo will present this 2009 paper from Nadine Ravel's group in Lyon, France: "The way an odor is experienced during aversive conditioning determines the extent of the network recruited during retrieval."
20 November: Matt Lewis will present a paper on glomerular computations from the Schoppa lab: "Control of On/Off Glomerular Signaling by a Local GABAergic Microcircuit in the Olfactory Bulb"
27 November: NO MEETING.
4 December: Sam Dillon.
Monday, 7 December is the date of the CPL Undergraduate Symposium.
11 December: ??
18 December: ??
The CPL Undergraduate Research Symposium will be held on Monday 7 December, from 1:00 - 4:00 pm (during study week), in the Whitaker room. The Whitaker room is on the fourth floor of Corson-Mudd Hall; take the elevator (or the adjacent stairwell) to the fourth floor, bear left as you emerge and the door is right in front of you. (The atrium stairwell does not go up to the fourth floor).
Fridays from 10:15 am - 12:00 noon in the Rosenblatt Room (3rd floor, Corson-Mudd Hall).
6 February: NO MEETING.
13 February: Organizational meeting; 5-10 minute updates by everybody on their present projects.
20 February: NO MEETING.
27 February (c): Shane Peace -- Spread of bulb-infused drugs measured with fluorescently-tagged muscimol.
6 March: Christiane -- Overview of CPL theory of noradrenergic function in the olfactory system
13 March: Sam Dillon -- ovariectomy techniques and project update.
20 March: SPRING BREAK -- meeting TBD (if any, will be in W358 Mudd Hall)
27 March: Laura Manella
3 April: Olga Escanilla
10 April: Anuttama Sheela Mohan -- preview of CBM "Research in Progress" talk on 4/15
17 April: Leo Arellanos (Meet in W358 Mudd Hall).
24 April (t): Erin Johnson
1 May: Dipesh Chaudhury
The CPL Undergraduate Research Symposium will be held on Monday 4 May, from 1:00 - 4:00 pm (during study week), in the Whitaker room. The Whitaker room is on the fourth floor of Corson-Mudd Hall; take the elevator (or the adjacent stairwell) to the fourth floor, bear left as you emerge and the door is right in front of you. (The atrium stairwell does not go up to the fourth floor).
Tuesdays from 9:00 - 11:00 am in the Rosenblatt Room
16 September: Thom and Christiane; Organization and Introductions.
30 September: Christiane will lead a discussion of Tsuno, Kashiwadani, and Mori 2008.
7 October (c): Dipesh will present his work.
14 October (t):
21 October: Anuttama will present.
28 October: Sam will present.
4 November: Christiane will lead a discussion of Fantana et al., 2008
11 November: Shane will present.
18 November: NO MEETING - SFN
25 November: Olga will present.
2 December (t): Christiane will present*.*
9 December (c): NO MEETING - come to undergrad symposium on 12/8 instead.
The CPL undergraduate research symposium will be held on Monday December 8th, from 1:00 - 4:00 pm (during study week), in the Whitaker room. The Whitaker room is on the fourth floor of Corson-Mudd Hall; take the elevator (or the adjacent stairwell) to the fourth floor, bear left as you emerge and the door is right in front of you.
16 December (c): Alexandra will present.
http://www.nature.com/articles/ncomms13721