...

• On linux it is necessary to have a Quadro FX Nvidia card with a 3 pin DIN connector. Non quadro cards and quadro cards that support 3D under windows but do not have the connector (like the Quadro M2000) will not work under Linux. This makes the cheapest new card at the time of writing the Quadro m4000 at $799.99.
• For the current quadro cards, as a result of NVIDIA not updating drivers (except for security patches) for legacy cards they will NOT work under CentOS 7 running GNOME or any other distribution of GNOME beyond GNOME 3.8 (as compositing is now a part of the environment that cannot be removed).
• Switching to a different desktop environment from GNOME should let the cards run under CentOS7 as long as the new desktop environment has compositing turned off by default or offers the option of disabling compositing (LXDE ,and XFCE and KDE are viable alternatives at time of writing).

See also