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For some chemists (mostly theoretical chemists), they benefit from systems which are up 24x7. For those researcher who don't have such persistent needs, they may be able to save huge enormous amounts using the cloud by paying only for the resources you actually use.

If there are acceptable down times, bring things down and don't pay for the resources.  There are lots of configurations you can play with to make sure that you have the resources ready when you need them.  This includes configuring your system to spawn additional resources when utilization is high and taking resources away when utilization is low or completely shutting down all resources when the service is not being used. CIT has been using Docker to containerize applications, you can read about it here:

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